Endocrine Abstracts

Introduction: Multiple studies have evaluated the efficacy of SGLT-2 inhibitors (SGLT2i) and GLP-1 receptor agonists (GLP1ra) in patients with type 2 diabetes mellitus (T2DM). However, their efficacy in clinical practice is less known in patients receiving insulin and few are the studies that compare use of SGLT2i vs GLP1ra as add-on therapy to insulin. This study aims to assess clinical efficacy of both treatments in a cohort of patients with T2DM on insulin and poor glycemic...

Introduction: Predictors for therapeutical response of SGLT-2 inhibitors (SGLT2i) is scarcely studied. The aim of the study was to retrospectively analyse the clinical parameters that contribute to the therapeutic outcomes of SGLT2i.Methods/design: We enrolled 75 patients with type 2 diabetes mellitus (T2DM), treated with SGLT2i for longer than three months. The patients were divided into two groups: good responders (if HbA1c-lowering effects were &#8805...

Introduction: Association between liver fibrosis and body mass index (BMI) is well known in HIV/HCV patients, is linked to worse lipid profile and is widely used to predict liver fibrosis in this population. Nevertheless, recent studies show a stronger link between dyslipidemia and liver stiffness with visceral adiposity index (VAI) in general population. The main aim of this study was to investigate the accuracy of VAI and BMI as predictors for liver fibrosis and dyslipidemia...

Introduction: Megestrol acetate (MA) is commonly used to promote weight gain in patients with HIV infection. Adrenal insufficiency (AI) has been reported as an adverse effect of MA but this association is not frequently recognized in clinical practice and only few cases develop symptoms of AI. We describe a case of symptomatic AI precipitated by Graves’ hyperthyroidism in a HIV patient on long-term MA treatment.Case report: A 44-year-old man with HI...

Introduction: There is solid epidemiologic evidence linking psoriasis and psoriatic arthritis (PsA) to cardiovascular risk factors and an increased risk for developing cardiovascular diseases. Despite this, dietetic advice is not routinely performed in clinical practice in patients with inflammatory arthropathies and the potential effect of diet on metabolic profile and inflammatory activity is few studied in these patients. This research aims to describe dietetic habits of a ...

Introduction: Patients with rheumatoid arthritis (RA) face an increased risk of developing premature cardiovascular disease and limited ability to modify risk factors such exercise or dietetic habits. Influence of exercise, dietetic habits or treatment on lipid profile has been little studied in patients with RA. Here we aim to determine differences in lipid profile between two cohorts of patients with RA with different habits and patterns of treatment.M...

Introduction: Pheochromocytomas (PCCs) and paragangliomas (PGL) are rare but unique tumors. Only 10% of PCCs are malignant, defined by metastases. Metastases can be seen at diagnosis of the primary tumor or develop even 20 years later. Approximately half of patients with metastatic PCC/PGL have inherited SDHB mutations.Case report: A 45-year-old man was referred to Urology for curvature of the penis and painful erections. Among his medical background hig...

Introduction: Vitamin D insufficiency is very common among Spanish adults. It is well established there is an inverse relationship between vitamin D and PTH levels. The diagnostic approach of an increased serum PTH concentration in a normocalcemic normophosphatemic patient is frequent in routine practice and the deficiency of vitamin D is the major cause of secondary hyperparathyroidism (SHPT). The aims of this study were to evaluate the prevalence of SHPT in a cohort of normo...

Introduction: Obesity is one of the most important problems worldwide in recent times. Groupal lifestyle intervention programmes are efficacious in the management of obesity. While exercise and healthy dietary habits have consistently been shown to improve various metabolic markers, adherence to these behaviors is low and methods that increase adherence to health behaviors are needed.Objective: The primary objective of this study is to evaluate the effec...

Introduction: 46 XX testicular DSD (disorder of sex development) is a rare syndrome characterized by 46 XX karyotipe, male external genitalia, azoospermia, sterility and usually hypergonadotropic hypogonadism in adulthood. Approximately 85% of individuals present after puberty with normal penile size, small testes and gynecomastia.Case report: We present a 34-year-old male who was referred for endocrine evaluation due to slightly high prolactin levels. H...